Twenty patients (BMI >35) were enrolled in the 12 week study with the Ideal Protein Protocol, Effect of a Ketogenic Diet on Advanced Lipid Profiles. Sixteen patients completed the study, constituting an 80% compliance rate. Besides noticeable results in weight reduction, findings indicate that the Ideal Protein Protocol also has a positive effect on lipid abnormalities, with significant reductions observed in glucose and triglyceride levels. The Ideal Protein Protocol also has a positive effect on insulin, insulin resistance, and parameters of metabolic syndrome.