The September 30, 2013 edition of JAMA Internal Medicine reports that estradiol is safer than conjugated equine estrogen (found in Premarin) by causing fewer cardiovascular events. The risk of having a myocardial infarction and venous thromboembolism was higher in the equine estrogen group. The risk for ischemic stroke was similar in both groups. As a side note, estradiol is considerably less expensive than conjugated equine estrogen.
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