Trigger point injections (TPIs) are outpatient procedures to relieve pain caused by trigger points. These small knots can develop in fascia tissues or muscles and cause pain. It’s often used when treatments like physical therapy don’t work to eliminate pain. TPIs are intra-muscular injections that contain a local anesthetic (Serapin, Lidocaine or Marcaine) to reduce pain. It’s injected into the muscle sites that are causing pain. Common treatment sites include the arms, legs, back, shoulders, and neck.